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To us, a multidisciplinary approach to drug discovery, involving the generation of truly novel molecular diversity from natural product sources, combined with total and combinatorial synthetic methodologies and including the manipulation of biosynthetic pathways, will continue to provide the best solution to the current productivity crisis facing the scientific community engaged in drug discovery and development.
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As was done previously, the cancer data will be presented as a stand-alone section from the beginning of formal chemotherapy in the very late 1930s or early 1940s to the present, but information from the last 34 years will be included in the data sets used in the overall discussion.
Currently indications for albendazole include echnicoccosis, cysticercosis and strongyloidiasis against which it is more effective than mebendazole (largely because it is better absorbed).
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Ramirez T, Benitez-Bribiesca L, Ostrosky-Wegman P, Herrera LA: In vitro effects of albendazole and its metabolites on the cell proliferation kinetics and micronuclei frequency of stimulated human lymphocytes.
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The personal comments, in which apparent deficiencies of data have been noted, reflect my own view of what non-clinical test results might now be expected in a brand new registration dossier.
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It is now 18 years since the publication of our first review covering drugs from 1984 to 1995; 12 years since the second, which covered the period from 1981 to 2002; eight years since our third, covering the period 1981 to the middle of 2006; and four years since our last full analysis (covering the period 1981 to 2010), of the sources of new and approved drugs for the treatment of human diseases.
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Albendazole had to be withdrawn in 5 patients because of adverse effects, although in 3 the withdrawal was only temporary.
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These concepts of drug-likeness and druggability have been extended to proteins and genes for target identification and selection.
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Albendazole is a benzimidazole carbamate anthelmintic structurally related to mebendazole () and with similar activity.
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That vital experience in the target species will almost always supersede any need for additional animal or other laboratory experiments.
Trends in the RO5 literature explosion that can be discerned are the further definitions of drug-like.
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For example, in the area of cancer, over the time frame from around the 1940s to the end of 2014, of the 175 small molecules approved, 131, or 75%, are other than “S” (synthetic), with 85, or 49%, actually being either natural products or directly derived therefrom.
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Organized Alphabetically by Generic Name within Source generic name trade name year introduced reference page source H-101 none given a 2005 DNP 19 46 B alemtuzumab Campath 2001 DNP 15 38 B bevacizumab Avastin 2004 ARMC 40 450 B celmoleukin Celeuk 1992 DNP 06 102 B cetuximab Erbitux 2003 ARMC 39 346 B denileukin diftitox Ontak 1999 ARMC 35 338 B ibritumomab Zevalin 2002 ARMC 38 359 B interferon alfa2a Roferon-A 1986 I 204503 B interferon, gamma-1a Biogamma 1992 ARMC 28 332 B interleukin-2 Proleukin 1989 ARMC 25 314 B mobenakin Octin 1999 ARMC 35 345 B pegaspargase Oncaspar 1994 ARMC 30 306 B rituximab Rituxan 1997 DNP 11 25 B tasonermin Beromun 1999 ARMC 35 349 B teceleukin Imumace 1992 DNP 06 102 B tositumomab Bexxar 2003 ARMC 39 364 B trastuzumab Herceptin 1998 DNP 12 35 B aclarubicin Aclacin 1981 I 090013 N angiotensin II Delivert 1994 ARMC 30 296 N arglabin none given a 1999 ARMC 35 335 N masoprocol Actinex 1992 ARMC 28 333 N paclitaxel Taxol 1993 ARMC 29 342 N paclitaxel nanoparticles Abraxane 2005 DNP 19 45 N pentostatin Nipent 1992 ARMC 28 334 N peplomycin Pepleo 1981 I 090889 N solamargines Curaderm 1989 DNP 03 25 N alitretinoin Panretin 1999 ARMC 35 333 ND amrubicin HCl Calsed 2002 ARMC 38 349 ND belotecan hydrochloride Camtobell 2004 ARMC 40 449 ND cladribine Leustatin 1993 ARMC 29 335 ND cytarabine ocfosfate Starsaid 1993 ARMC 29 335 ND docetaxel Taxotere 1995 ARMC 31 341 ND elliptinium acetate Celiptium 1983 I 091123 ND epirubicin HCI Farmorubicin 1984 ARMC 20 318 ND etoposide phosphate b Etopophos 1996 DNP 10 13 ND exemestane Aromasin 1999 DNP 13 46 ND formestane Lentaron 1993 ARMC 29 337 ND fulvestrant Faslodex 2002 ARMC 38 357 ND gemtuzumab ozogamicin Mylotarg 2000 DNP 14 23 ND hexyl aminolevulinate Hexvix 2004 I 300211 ND idarubicin hydrochloride Zavedos 1990 ARMC 26 303 ND irinotecan hydrochloride Campto 1994 ARMC 30 301 ND miltefosine Miltex 1993 ARMC 29 340 ND pirarubicin Pinorubicin.
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In addition to the citations given in our previous reviews covering these methodologies, there have been some recent publications that can be consulted in order to demonstrate how “privileged structures from Nature” are demonstrated sources of molecular skeletons around which one may build libraries.
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When albendazole is used to treat cystic hydatid disease, it is usually taken for 28 days, followed by a 14-day break, and repeated for a total of three cycles.
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